Abstract: Expression of c-erbB-2 and P⁵³ oncoprotein was examined by immunohistochemistry in paraffin sections from 64 cases of endometrial carcinoma,16 cases of noraml endometrium,32 cases of endometium hyperplasia and 5 cases endometrium polyp.The results showed;(l)The positive rate of expression of c-erbB-2 and P⁵³ in endometrial carcinoma were 60.9% and 37.5% respectively.They were significantly higher than normal endometrium,endometium hyperplasia and endometrium polyp.(2)The positive expression of c-erbB-2 and P⁵³ in endometrial carcinoma were associated with clinical stage and histologic grade,but not with pathologic type and depth of muscle invasion.(3)The 3 or 5 year survival rate of patient with the positive expressin of c-erbB-2 and P⁵³ were significantly lower than that wilh the negative expression.These results suggested that c-erbB-2 and P⁵³ were valuable maker to understand the dgree of mailigancy and evaluate prognosis of disease.