可手术的Ⅲ期乳腺癌术前化疗疗效观察

Curative Effects of Preoperative Chemotherapy in the Treatment of Stage Ⅲ Operable Breast Cancer

摘要: 从1981年1月至1991年12月,我们共收治可手术见期乳腺癌61例,其中术前化疗36例,非术前化疗25例。术前化疗组中,经尺动脉插管给药19例,静脉给药17例,有效率分别为73.7％和76.5％(P>0.05),5年生存率分别为68.4％和70.6％(P>0.05),总有效率和5年生率率分别为75.0％和69.4％。5年生存率明显高于非术前化疗组的36.0％(P<0.05)。结果表明:术前化疗对改善可手术Ⅲ期乳腺癌的预后有其重要的意义。

Abstract: Sixty-one patients with stage Ⅲ operable breast cancer were treated from Jan.1981to Dec, 1991.All patients were divided into preoperative chemotherapy group (36cases) and control group (25 cases).In the group of preoperative chemotherapy, nineteen patients were treated by trans-catheter intraarterial infusion, and seventeen patients were treated by venoclysis.The effective rate to preoperative chemotherapy intwo groups was 73.7% and 76.5% (P<0.05),respectively.The 5-year survival rate was68.4% and 70.6% (P<0.05),respectively.Total effective rate and 5-year survival rateof the preoperative chemotherapy were 75.0% and 69.4%, respectively.The 5-yearsurvival rate was higher than that of control group (36.0%,P<0.05).The results indicate that the preoperative chemotherapy on the prognosis of stage Ⅲ operable breastcancer has an important effect.