Abstract: The present paper has investigated the prognostic significance of Nm23 and C-erb B-2expression in 156 patients with breast cancer utilizing immunohistochemical staining S-Pmethod. The results show that Nm23 positive expression rate is 64. I percent (100/156)andC-erb B-2 positive expression rate is 50. 64 percent (79/156). Both of Nm23 and C-erb B-2expression have no correlation with age of the patients. Nm23 expression has no significantrelation with the histological type and clinical stage,but significantly relates with lymph nodemetastasis and postoperation survival time, C-erb B-2 expression significantly relates withhistological type,lymph node metastasis,clinical stage and postoperation survival time.