Abstract: Giant cell tumor of bone (GCT)is a semi—malignant tumor.There are high recurrentrates in this tumor after operation.7 specimens of GCT proved by pathology were cultured,then the chemosensisitivity of the primary cultures were tested by using MTT method,The results showed there were middle degree sensitivity to GCT in usual dose (1/250 of one clinical dose )of cisplachitin (CDDP)and adriamycin (ADM),The results of chemosensitivity test of echelon dense of chemical drug showed the lowest effective dense of ADM,CDDP and MTX were 0.4ug/ml, 2ug/ml, 3ug/ml, It is concluded GCT may be treated by ADM and CDDP to reduce the recurrent rate of GCT after operation. As the effeective dense of the drug is high,usual injection in vein and local giving are not suited,and the local treatment by drug delivery system made out by good sustained release carrier and sensitivity chemical drug may be the only effective mothed.