颅底良性肿瘤立体定向放射外科治疗

Stereotactic Radiosurgery for Benign Tumors of Skull Base

摘要: 目的探讨颅底良性肿瘤的SRS治疗效果。方法 1994 年7 月至1996 年12 月对22例（23 个肿瘤）手术后残存或者复发的颅底良性肿瘤实施了SRS治疗。结果治疗后大多数病人（1822）的临床症状获得改善，无治疗相关的永久性颅神经损伤发生。影像学观察提示有9 个肿瘤体积缩小，13 个肿瘤体积无变化，1 例肿瘤增大。有813 例（61-5 % ）神经鞘瘤病变中心表现出CT影像的低密度。结论对经过选择的颅底良性肿瘤实施SRS治疗，可以获得良好的局部肿瘤控制效果和比较低的治疗并发症。

Abstract: Objectibve To as kresponse of benign tumors of skull base to SRS. Methods 22 patients with 23 recurrent or residual bening skull base tumors were treated by LINAC-based stereotactic radiosurgery(SRS). Results After a median follow-up of 36 month,82% of patients got symptomatic improvement,tumor control rate is 96%,1 Schwannoma received reoperation at 24 month after SRS since local tumor recurrence. No permanment radiation injury was observed. Conclusion SRS would provide a good treatment result for selected casesof skull base benign tumors with minor toxicity in majority of patients.