恶性淋巴瘤中MTS1-p16基因的缺失
Deletions of MTS1/p 16 Gene in Lymphoma
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摘要: 目的 研究MTS1p16基因在恶性淋巴瘤中的变化。方法 采用多重PCR 检测34 例非何杰金淋巴瘤（NHL） 和15 例健康人体外周血DNA 的p16gene Exon2 纯合子缺失。结果 34 例NHL中有4 例有p16gene Exon2 纯合子缺失。结论 MTS1P16gene 变异可能在非何杰金淋巴瘤的发生发展中起作用。Abstract: Objective To investigate the alteration of MTS1/p 16 gene in lymphoma. Methods A total of 34 non-Hodgkin's lymphoma and 15 controls DNA specimens were examined for homozygous deletion of MTS1/p 16 gene Exon2 by Differential PCR. Results The results showed that 4 of 34 non-Hodgkin's lymphoma DNA specimens were found the deletion of MTS1/p 16 gene Exon2, with a 11 8%(4/34) MTS1/p 16 gene EXon2 deletion rate. Conclusion The results suggest that MTS1/p 16 gene alterations may play a role in the progression of non-Hodgkin's lymphoma.
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