Abstract: Objective To investigate the correlation between the expression of vascular endothelial growth factor(VEGF) and its receptor KDR and angiogenesis,They observed the localization and distribution of VEGF and KDR in various differentiated gastric cancer tissues. Methods VEGF and KDR were detected in 50 gastric carcinoma (GC) by immunohistochemical ABC technique.Microvessel density was determined by immunostaining for factor Ⅷrelated antigen.Reaults VEGF positive rate was 50%,and VEGF was mainly localized to the cytoplasm or the membrane of the gastric cancerous cell;KDR wsa mainly localized in the vascular endothelial cell in gastric cancer tissues and their related Peri Cancerous tissue.Microvessel density was significantly higher in VEGF positive tumor (13 905±7 24) than in VEGF negative tumors (6 50±2 10) ( P 0 05).With VEGF positive intensity increasing,microvessel density become more high. Conclusion VEGF might have mainly paracrine effect upon the endothelial cell to promote angiogenesis.Our data also hinted at the possibility that VEGF might have an autocrine effect upon the gastric cancer cell itself.