福建消化道肿瘤患者氮-乙化酶多态性调查

Study on the NAT Polymorphism smong Gastrointestinal Carcinoma Patients in Fujian

摘要: 为探讨N-乙酰化酶(NAT)多态性与消化道肿瘤遗传易感性的关系，检测了70例消化道肿瘤患者(胃癌34例、大肠癌28例、肝癌8例)和107例非肿瘤对照的N-乙酰化酶多态表型。结果显示70例消化道肿瘤患者27例为慢型(38.57%)；107例对照20例为慢型(18.69%)，两者之间有显著差异。OR值为2.67(95%CI 1.28~5.61)，提示N-乙酰化酶表型慢型患消化道肿瘤的危险性增加1.67倍。本调研为深入探讨消化道肿瘤的病因学并加强预防提供了新的线。

Abstract: In order to clarify the relationship between the polymorphism of N-Acetyltransferase (NAT) and genetic susceptibility to gastrointestinal Carcinoma. Phenotypy of NAT polymorphism was determined among 70 patients with gastrointestinal carcinoma (34 gastric cancer. 28 colerectal cancer and 8 primary liver cancer) and 107 health controls in Fujian. The results showed that the slow type of NAT was 38 57% (27/70) for cases, and 18 69% (20/107) for the controls. The difference between the cases and controls was statistically significant ( x²=8 15, P =0 0043).The odds ratio was 2 67 (95% CI 1 28～5 61), which suggest that persons with slow type NAT have 1 67 times of the increased risk of gastrointestinal carcinoma, This investigation would throw a new clue into the study of aetiology and prevention of gastrointesinal carcinoma.