Abstract: Objective To discuss the method for granisetron tablets in the prevention of acute vomiting induced by chemotherapy. Methods Forty-five patients with chemotherapy comprise cisplatin,adriamycin,and dacarbazine underwent anti-emetic therapy from November 1996 to July 1997.The chemotherapy regimens include CHOP, ABVD, CAP CAF,EPand FP.The dose of PDD was 70～80mg/M2,ADM was 40～50mg/M2 and DTIC was 300mg/M2.Granisetron 3mg p.o.at 3 hours before chemotherapy on the first day. Results The rates of complete control-free of vomiting were 64.4%,64.4%,71.1%,82.2% and 88.9% D1-5.The rates of overall control were 86.7%,88.9%,88.9%,91.1% and 93.3% D1-5. Conclusion Granisetron 3mg p.o.at 3 hours before chemotherapy on the first day is effective in the prevention on acute vomiting induced by chemotherapy.