Abstract: To establish a new method to detect the tumor marker in patients with gynecologic neoplasms.It's important to diagnose malignant tumor in women and reduce the gynecologic neoplasma incidence rate.The level of monohydroxyphenyl substance (MHP) was detected in the urine samples collected from normal women,the patients with uterine myoma, cervical neoplasm,ovarian cancer.The results showed that the content of MHP among those paticnts,there were significant difference(P<0.001).The results suggested that the high MHP level in urine may be related to the formation and development of gynecologic neoplasms.Urinary MHP could be one of the markers in early gynecologic neoplasms.