Abstract: Objective: To determine the relation of microvessel density (MVD)to the prognosis and the clinicopathological factors in axillary-node-negative breast cancer (ANNBC). Methods: MVD in 120 cases paraffin specimens of ANNBC. were examinated using imminohistochemistry technique. The relationship between MVD and overall survival (OS), relapsefree survival (RFS), metastasis-free survival (MFS) were analysed, respectively, as well as it was done between MVD and five clinicopathological factors. Results: The mean MVD was 38.21 ±18.72. It didn't relate to those clinicopathological factors. MVD in relapse and metastasis group which was apparently higher than that in desease-free group; OS, RFS, MFS curve in higher MVD group (MD >38) were significiantly lower those that in lower MVD group (MVD ≤38), respectively ; COX model indicated that MVD was an independent prognostic factor in ANNBC. Conclusion: MVD may be a good prognostic indicator for patients with ANNBC.