Abstract: Objective: In order to investigate the relationship between Helicobacter Pylori (Hp)infection and gastric cancer. Methods: A 1:1 matched casecontrol study was conducted in Changle, which is one of gastric cancer highest mortality in the world. Results: The Hp infection rate was 63.68 % in all subjects. No significant difference (P >0.05) was seen between cases and controls. Hp infection rates were 68.18 % in gastric adenocarcinoma cases, and 56.00 % in gastric cardia cancer cases. The prevalence of Hp was high in the risk areas of gastric cancer. Conclusion: The combined effect between Hp infection and other risk factors (fish sauce, less consumption of fresh vegetables, bad dietary habits) played an important role in gastric cancer.