高级搜索

维生素C阻断亚硝胺在体内合成的实验观察

维生素C阻断亚硝胺在体内合成的实验观察[J]. 肿瘤防治研究, 1974, 2(3): 29-33.
引用本文: 维生素C阻断亚硝胺在体内合成的实验观察[J]. 肿瘤防治研究, 1974, 2(3): 29-33.

维生素C阻断亚硝胺在体内合成的实验观察

  • 摘要: 一些亚硝胺类化合物有致癌作用,其中有的主要是引起动物发生食管癌。这类化合物存在于环境中,某些食物也含有一定量的亚硝胺。我们曾初步分析河南省林县和范县的主要食物样品,在林县124个样品中,有29个的薄层色谱分析含有亚硝胺。

     

  • 1 Druckrey, H.,Preussmann, R.,Ivankovic S., and Schmuhl,D. Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten. Z. Krebsforseh.,69:103-201, 1967.
    2. Magee, P. N., and Barnes, T. M. Car-einogenie nitroso-Compounds. Adv. Cancer Res.,10.176-181, 1967.
    3. 中国医学科学院林县食管癌防治研究队。盒管癌亚硝胺病因的研究一、林县与范县食品中亚硝胺类化合物的分析。杭癌简讯(林县),1:5-15, 1974.
    4. Sera, N.P.,Smith, D. C., and Schwi-nghamer, L. Formation of N-nitrosamines fromsecondary amines and nitrite in human and animalgastric juice. Fd. Cosmet. Toxicol., 7:301一307,1969.
    5. Lijinsky, W., and Epstein, S. S. Nitr-osamines as environmental carcinogens. Nature,225,21-23, 1970.
    6. Sander, J.,Bulrkle, G.,and Schweinsberg,F. Induefion of tumors by nitrite and secondary amines or amides. in Topics in Chemical Carcino- genesis Tokyo Univ. Press, 297-312, 1972.
    7. Mirvisla, S. S., Wallcave, L. E., and Shubik, P. Ascorbate-nitrite reaction } Possiblemeans of blocking the formation of carcinogenic N一nitroso compounds. Science, 177:65-68, 1972.
    8. Sen,N. P.,and Dalpe,C. A simple Thinla-ver chromatographic technique for The semi-qaaan- titative determination of volatile nifiosamines in alco- holic beverages. Analyst 1972. 97.216-220.
    9. Ivankovic, S.,Preussmann, R.,Schmahl , D. and Zeller, T. Verhaltung von Nitrosamid-bedi-ngtem Hydrocephalus durch Ascorbinsaure nach praenataler Gabe von Aethylharnstoff and Nitrit ars Ratters. Z. Krebsforsch., 79:145-147, 1973.
    10 Greenblatt, M. Ascorbic acid blocking of amirsopyrine nitrosation in NZO/Bl mice. J. Nat. Cancer Inst., 50:1055-1056, 1973.
    11 Kumm, J. J., Dashman, T.,Convey, A. H., and Burns, J. J. Protective effect of asco-rbic acid on hepatotoxicity caused by sodium nitr-ite plus aminopyrine. Proc. Nat. Acad. Sci.,U S. A., 70:747-749, 1973.
计量
  • 文章访问数:  1591
  • HTML全文浏览量:  48
  • PDF下载量:  392
  • 被引次数: 0
出版历程
  • 刊出日期:  1974-09-04

目录

    /

    返回文章
    返回
    x 关闭 永久关闭