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扶正培本法治疗恶性肿瘤作用机制的研究进展

李枋霏, 李 杰

李枋霏, 李 杰. 扶正培本法治疗恶性肿瘤作用机制的研究进展[J]. 肿瘤防治研究, 2014, 41(06): 674-679. DOI: 10.3971/j.issn.1000-8578.2014.06.037
引用本文: 李枋霏, 李 杰. 扶正培本法治疗恶性肿瘤作用机制的研究进展[J]. 肿瘤防治研究, 2014, 41(06): 674-679. DOI: 10.3971/j.issn.1000-8578.2014.06.037
LI Fangfei, LI Jie. Mechanism of Fuzheng Peiben Therapy in Treating Malignant Tumor[J]. Cancer Research on Prevention and Treatment, 2014, 41(06): 674-679. DOI: 10.3971/j.issn.1000-8578.2014.06.037
Citation: LI Fangfei, LI Jie. Mechanism of Fuzheng Peiben Therapy in Treating Malignant Tumor[J]. Cancer Research on Prevention and Treatment, 2014, 41(06): 674-679. DOI: 10.3971/j.issn.1000-8578.2014.06.037

扶正培本法治疗恶性肿瘤作用机制的研究进展

基金项目: 国家自然基金资助项目(81072802,81273946)
详细信息
    作者简介:

    李枋霏(1988-),女,硕士在读,主要从事中医药对肿瘤免疫调节的分子机制研究

    通信作者:

    李杰,E-mail:drjieli2007@gmail.com

  • 中图分类号: R730.5;R273

Mechanism of Fuzheng Peiben Therapy in Treating Malignant Tumor

  • 摘要: 恶性肿瘤是我国的常见病多发病,目前,各种治疗手段在防治肿瘤复发与转移方面有了许多进展,但是恶性肿瘤总体生存期延长并不显著。中医在改善恶性肿瘤患者生活质量、延长生存期方面具有显著优势,针对恶性肿瘤发病及病机特点提出的扶正培本治法是治疗恶性肿瘤的基本法则。扶正培本法包括扶正培本单药和扶正培本复方,由于中药组方的灵活性和成分的复杂性,其抗肿瘤效应可能是多靶点、多途径协同作用的结果。现代研究表明,中医扶正培本法治疗恶性肿瘤具有增强和调节机体免疫能力、调节肿瘤细胞外基质平衡、抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抗肿瘤血管生成和淋巴管生成、阻止基因突变等多种作用。本文就近来年关于扶正培本法治疗恶性肿瘤的机制研究进行总结。

     

    Abstract: Cancer is an increasing common disease in China. Currently, much progress of various kinds of treatments has been made in prevention of tumor recurrence and metastasis, but there is no significant prolongation in overall survival of the patients. Chinese medicine has notable advantages in improving patients' quality of life and prolonging their survival. According to the disease and pathogenesis characteristics of cancer, Fuzheng Peiben therapy is proposed as the basic rule in the treatment of malignancy in Chinese medicine, including Fuzheng Peiben monotherapy and combotherapy. Since its flexible formation and complex composition, the anti-tumor effect may be synergy results of multi-target and multi-channel. Modern research has shown that Fuzheng Peiben therapy can enhance and regulate the immune capacity,regulate the balance of tumor extracellular matrix, inhibit tumor cell proliferation, induce tumor cell apoptosis, suppress angiogenesis and lymphangiogenesis and prevent the DNA mutations. We summarize recent mechanism research of Fuzheng Peiben therapy in the treatment of malignancy.

     

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出版历程
  • 收稿日期:  2013-06-03
  • 修回日期:  2013-08-17
  • 刊出日期:  2014-06-24

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