Clinicopathological Features of Adenomatoid Tumors of Uterus
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摘要: 目的 探讨子宫腺瘤样瘤的临床病理特征及鉴别诊断要点。方法对11例发生于子宫的腺瘤样瘤的临床信息、组织病理学特征以及免疫组织化学表型进行回顾性分析。结果患者多为生育期女性，最常伴发的疾病为子宫平滑肌瘤(36.7%）。肿瘤镜下形态多样，可见印戒样细胞、裂隙样腔隙、多囊网状或不规则大囊状结构等。免疫组织化学染色panCK (100%）、calretinin(100%）及HBME-1(82%）强阳性，CK5/6弱阳性(27.3%），而CD31(0）为阴性。主要应与腺癌、平滑肌瘤等相鉴别。结论 仔细取材，准确把握其镜下形态及鉴别诊断要点，合理应用免疫组织化学技术，有助于正确诊断该疾病，避免临床的误诊及误治。
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关键词:
- 腺瘤样瘤 /
- 子宫 /
- calretinin /
- 临床病理 /
- 鉴别诊断
Abstract: Objective To investigate the clinicopathological features and key points of different diagnosis of Adenomatoid Tumors(ATs）of the uterus. Methods The clinical，histopathological and immunohistochemical features were evaluated in 11 cases of ATs retrospectively. Results Most patients were women of child-bearing period，the disease was often accompanied by uterine smooth muscle tumors (36.7%).A variety of microscopic patterns of tumor including signet ring-like cells，crack-like cavities，polycystic reticular structure and irregular large cystic structure were presented.Immunohistochemical staining showed strong positive for panCK(100%），calretinin(100%） and HBME-1(82%），weak positive for CK5/6(27.3%），but negative for CD31(0）.The main different diagnosis was adenocarcinoma and leiomyoma. Conclusion Careful dissection，accurately grasping of microscopic morphology，key points of different diagnosis and immunohistochemistry techniques are useful in establishing a correct diagnosis of ATs，and avoiding misdiagnosis and mistherapy of clinical managment.-
Key words:
- Adenomatoid tumors /
- Uterus /
- Calretinin /
- Clinicopathology /
- Different diagnosis
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[1] Masson P RJ，Simard L.Le mesotheliome benin de la sphere genitale[J].Rev Can Biol，1942，1：720-751. [2] Hayes SJ，Clark P，Mathias R，et al.Multiple adenomatoid tumours in the liver and peritoneum[J].J Clin Pathol，2007，60(6)：722-724. [3] Sangoi AR，McKenney JK，Schwartz EJ，et al.Adenomatoid tumors of the female and male genitaltracts：a clinicopathological and immunohistochemical study of 44 cases[J].Mod Pathol，2009，22(9)：1228-1235. [4] Zhu Li，Li BZ.Clinical and pathological analysis of adenomatoid tumor of the uterus and ovaries[J].Zhonghua Bing Li Xue Za Zhi，2001，30 (1)：43-45.[朱力.李宝珠.子宫和卵巢腺瘤样瘤的临床病理分析[J].中华病理学杂志，2001，30(1)：43-45.] [5] Wachter DL，Wunsch PH，Hartmann A，et al.Adenomatoid tumors of the female and male genitaltract.A comparative clinicopathologic and immunohistochemical analysis of 47 cases emphasizing theirsite-specific morphologic diversity[J].Virchows Arch，2011，458(5)：593-602. [6] Nogales FF，Isaac MA，Hardisson D，et al.Adenomatoid tumors of the uterus：an analysis of 60cases[J].Int J Gynecol Pathol，2002，21(1)：34-40. [7] Amin MB.Selected other problematic testicular and paratesticular lesions：rete testis neoplasmsand pseudotumors，mesothelial lesions and secondary tumors[J].Mod Pathol，2005，18(Suppl 2)：S131-S145. [8] Young RH.Testicular tumors-some new and a few perennial problems[J].Arch Pathol Lab Med，2008，132(4)：548-564. [9] Cserni G，Kocsis L，Pusztai Z，et al.Endometrial adenocarcinoma with coexisting adenomatoidtumor of the uterus[J].Gynecol Oncol，2003，90(1)：207-210. [10] Hsieh CH，Lui CC，Huang SC，et al.Multiple uterine angioleiomyomas in a woman presenting withsevere menorrhagia[J].Gynecol Oncol，2003，90(2)：348-352. [11] Tiltman AJ.Adenomatoid tumours of the uterus[J].Histopathology，1980，4(4)：437-443. [12] Schwartz EJ，Longacre TA.Adenomatoid tumors of the female and male genital tracts express WT1[J].Int J Gynecol Pathol，2004，23(2)：123-128. [13] Delahunt B，Eble JN，Nacey JN，et al.Immunohistochemical evidence for mesothelial origin ofparatesticular adenomatoid tumour[J].Histopathology，2001，38(5)：479.
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