组织蛋白酶D在乳腺癌浸润转移中作用的研究

吴凤云; 刘运江

doi:10.3971/j.issn.1000-8578.2065

组织蛋白酶D在乳腺癌浸润转移中作用的研究

河北医科大学第四医院外一科; 050011石家庄

详细信息

通信作者:
吴凤云

中图分类号: R737.9
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出版历程
- 收稿日期: 2003-11-02
- 修回日期: 2004-05-19
- 刊出日期: 2004-12-04

The Role of Cathepsin D on the Invasion and Metastases of Breast Cancer

The Fourth Hospital of Hebei Medical Univercity; Shijiazhuang 050011; China

More Information

Corresponding author:
WU Feng-yun

摘要

摘要: 目的　通过研究组织蛋白酶D与乳腺癌传统临床指标及部分生物学因子的关系, 探讨组织蛋白酶D在乳腺癌浸润转移过程中的作用。方法　采用免疫组化SP法对组织切片进行染色处理。结果　16 0例乳腺癌组织Cath D的总表达率为 6 8.8% (110 / 16 0 ) ;Cath D表达与临床分期、肿块大小、组织学分级、c erbB 2、VEGF呈正相关 (P <0 .0 5 ), 与ER、PR表达呈负相关 (均P <0 .0 2 5 ) ;与淋巴结转移、月经状况、年龄无相关性 (均P >0 .0 5 )。结论　Cath D过度表达与乳腺癌的浸润及转移有密切关系 ;Cath D促进肿瘤细胞转移的主要途径是血行播散而非淋巴道 ;ER、PR阴性患者中Cath D的高表达, 提示应加强这部分病人的化疗及综合治疗。
- 组织蛋白酶D /
- 乳腺癌 /
- 浸润转移 /
- 临床生物学指标 /
- 免疫组织化学法
Abstract: Objective To investigate the role of cathepsin D in facilitating tumor cells invasion and metastases by comparing cathepsin D expression with clinical and biological indicators in breast cancer. Methods By immunohistochemical SP method. Results The positive rate of cathepsin D expression in all breast cancer patients was 68.8%(110/160). Cathepsin D expression was positive correlated with that of VEGF, c-erbB-2 as well as tumor size, clinical stage and histological grade (P< 0.01), but was negati...
- Cathepsin D /
- Breast neoplasms /
- Invasion and metastasis /
- Clinical and biological indicators /
- Immunohistochemistry