Knowledge, Attitude and Practice about Human Papillomavirus and HPV Vaccine in Chinese Mainland: A Meta-analysis
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摘要:目的
了解和评价中国大陆地区女性对人乳头瘤病毒及HPV疫苗相关知识的认知、态度和行为, 为预防和消除宫颈癌提供理论依据。
方法检索1995年1月1日到2021年1月31日在PubMed、Medline、CNKI和万方数据库等数据库收录的所有关于中国大陆地区女性人群中发表的有关HPV病毒及HPV疫苗相关知识的认知、态度和行为因素的相关研究。由两位研究者独立筛选文献、提取数据资料和评分≥5分的文献。卡方检验评价其异质性; Begg' s检验评价发表偏倚。
结果共有33篇文献纳入研究, 总人数为46013人。
结果显示: 人群HPV总知晓率为65.9%, 其中HPV总知晓率最低的是东北地区、农村地区及中学生分别为16.0%、41.2%和14.4%, 而最高的是华北地区、城镇及大学生人群分别为77.4%、56.3%和71.0%。人群HPV相关知识的主要来源是网络/微信公众号为38.9%, 家人/朋友来源最低为4.5%。人群对HPV疫苗相关知识知晓率为41.4%, 其中HPV疫苗相关知识总知晓率最高的是华东地区和医务人员分别为51.8%和69.7%, 而最低的是西南地区人群和中学生分别为23.6%和12.7%。
结论为尽快实现我国在2030年全面消除宫颈癌目标, 后续应加强人群对HPV和HPV疫苗相关知识的认知。
Abstract:ObjectiveTo understand and evaluate the knowledge, attitude and practice of female human papillomavirus and HPV vaccine in Chinese mainland.
MethodsWe searched the relevant studies about the knowledge, attitude and behavior factors of HPV infection and HPV vaccine published in PubMed, MEDLINE, CNKI and Wanfang databases about Chinese mainland women from January 1, 1995 to January 31, 2021.Two researchers independently screened the literatures, extracted data and the literatures with quality score≥5 points.Chi square test was used to evaluate its heterogeneity.Begg' s test was used to evaluate publication bias.
ResultsA total of 33 literatures were included, with a total number of 46013 people.The results showed that the total awareness rate of HPV in the population was 65.9%, the lowest rates were 16.0%, 41.2% and 14.4% in Northeast, rural areas and middle school students, respectively; while the highest rates of HPV were 77.4%, 56.3% and 71.0% in Central China, cities and towns and college students, respectively.The main source of HPV knowledge was the network/WeChat official account number (38.9%), and the lowest was family/friend (4.5%).The population's awareness rate of HPV vaccine related knowledge was 41.4%, the highest rates were 51.8% and 69.7% in East China and medical staff, respectively, while the lowest were 23.6% and 12.7% in Southwest and middle school students.
ConclusionIn order to achieve the total elimination of cervical cancer in China by 2030 as soon as possible, people should strengthen their awareness of HPV and HPV vaccine related knowledge.
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Key words:
- HPV infection /
- Ucognition /
- System evaluation
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Competing interests: The authors declare that they have no competing interests.作者贡献：石郑阳：数据分析、文章撰写郝金奇：数据分析石继海：课题指导苏征、刘书君：文献检索张希、徐慧芳：核对数据高静茹、付颖：提取数据、资料整理乔友林、余艳琴：课题设计、数据核对、指导文章
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图 2 HPV可通过性接触传播知晓情况的森林图
Figure 2 Forest map of people's awareness of HPV transmission through sexual contact
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