STAT-1 在膀胱癌组织中的表达及其临床意义

The Significance of STAT-1 Expression in Bladder Cancer

摘要: 目的检测信号转导和转录激活因子-1(STAT-1)在膀胱癌组织中的表达，并探讨其在膀胱癌发病机制中作用及其临床意义。方法应用免疫组织化学方法检测STAT-1在88例膀胱癌和12例正常膀胱组织中的表达。结果膀胱癌中STAT-1表达阳性率为78．4％，显著高于正常膀胱组织的41．7％。STAT-1表达水平与膀胱癌病理分级、分期及复发之间密切相关。结论 STAT-1异常表达与膀胱癌的发生、发展关系密切，而且是肿瘤生物学行为较有价值的标记物。

Abstract: Objective 　This study was designed to investigate the role of STAT-1 in the pathogenesis of bladder cancer and its relationship with tumor biological behaviors. Methods 　The expression of STAT-1 in 88 cases of cancerous tissues and 12 cases of normal bladder tissues was determined by immunotistochemical staining. Results 　The protein expression rates of STAT-1 in bladder cancer and normal bladder tissues were 78. 4% and 41. 7%, respectively ( P = 0. 033) . Expression of STAT-1 in bladder cancer was correlated with tumor grade, stage and recurrence ( P = 0. 043, P = 0. 008 and P = 0. 002) . Conclusion 　Abnormality of STAT-1 may play an important role in the tumor genesis of bladder cancer. Determination of STAT-1 can be used to indicate the tumor biological behavior.