MRP、LRP 在人大肠癌组织中的表达及临床意义

doi:10.3971/j.issn.1000-8578.788

MRP、LRP 在人大肠癌组织中的表达及临床意义

Expression and Clinical Significance of LRP and MRP in Human Colorectal Carcinomas

摘要

摘要: 目的检测MRP、LRP在人大肠癌组织中的表达，探讨其与临床病理相关因素（患者的年龄、性别、肿瘤的大小、分化程度、浸润深度、及淋巴结转移）的关系。方法采用免疫组化S-P法检测92例大肠癌组织中MRP、LRP的表达。结果 MRP、LRP在大肠癌中的阳性表达率分别为41．30％（38／92）、84．78％（78／92）且仅LRP与肿瘤的浸润深度相关。MRP、LRP的共表达率为39．13％，且两者具有关联性。结论 MRP、LRP在大肠癌组织中均高表达，与大肠癌的耐药性密切相关；且两者具有相关性，对其的深入了解有利于临床化疗方案的合理化，规范化，有助于化疗效果的提高。

Abstract: Objective 　To investigate the expression and clinical pathology associated factor of MRP and LRP. Methods 　Ninety-two paraffin embedded primary colorectal carcinoma specimens were examined by immunohistochemical staining (S2P) . Results 　Of the 92 tumor specimens examined, 38 cases (41. 30 %) and 78 cases (84. 78 %) were positively immunostained for MRP and LRP, respectively. 36 (39. 13 %) were positively immunostained for both MRP and LRP. And the two factors are related with each other. Positive immunostaining of LRP was just correlated with depth of tumor invasion. Conclusion 　These two drug resistance associated proteins were closely correlated with the multidrug resistance of colorectal carcinoma. To examine their expression may help guide rational comprehensive therapy of colorectal carcinomas.

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