肝癌癌旁组织DNA倍体检测的预后意义

Prognosis Signification of Measurement of DNA Ploidy in Para-cancer tissue on Patients with Primary Liver Cancer

摘要: 目的　探讨肝癌患者癌旁组织DNA倍体变化和预后的关系。方法　对42例原发性肝癌患者的癌旁组织的DNA倍体和S期细胞比率(SPF)进行了流式细胞术分析。结果　肝癌患者癌旁组织DNA异倍体检出率为59.5%。肝癌癌旁组织为DNA二倍体者的5年生存率和术后生存期均显著高于癌旁组织为异倍体的患者(分别为82.4%、65.8月±21.7月和32.0%、32.1月±23.6月，P均<0.01)。二倍体癌旁组织患者的生存率曲线明显高于癌旁异倍体病例。结论　癌旁组织出现DNA异倍体预示该肝癌患者的预后不良。

Abstract: Abstract：For studing the relationship of patient prognosis to DNA ploidy of para-cancer tissue in patients with primary liver cancer,DNA ploidy and SPF were measured on para-cancer tissue samples from 42 primary liver cancer by flow cytometry.The results showed that DNA aneuploidy rate of para-cancer tissue was 59.5%.The 5 year survival rate and survival time of patients with diploidy in para-cancer tissue were higher than that of patients with aneuploidy (82.4%，65.8 moons ± 21.7 moons and 32.0%,32.1% moons ± 23.6 moons,P<0.01 respectively).The survival rate line of cases with diploidy was higher than that of cases with aneuploidy.The above results provided objective evidence for grading patients as regards prognosis in primary liver cancer.