胰腺癌中p21ras、p53蛋白及PCNA的检测和临床意义
Clinical Significance of Expressions of p21 and p53 Proteins and PCNA in Pancreatic Cancer
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摘要: 目的 探讨p21ras、p53蛋白和增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)在胰腺癌发生、发展中的作用和临床意义。方法 应用免疫组化法对30例胰腺癌，3例正常胰腺组织中的ras基因产物p21、p53蛋白和PCNA进行检测，并结合临床资料分析。结果 胰腺癌中p21、p53蛋白表达正相关，阳性表达率分别为75%、53.33%；PCNA阳性表达率为43.39%±17.99%，并随胰腺癌恶性度的增加而增加，与预后、p53表达相关(P<0.05),与淋巴结转移、神经侵润及肿瘤大小无关(P>0.05)。结论 胰腺癌的发生发展过程是多种癌基因协同作用的结果；PCNA可作为判定胰腺癌恶性程度及预后的一项指标。Abstract: Objective To study the clinical significance and effect of the expression of p21、p53 protein as well as PCNA on the occurrence and development of pancreatic carcinoma. Methods p21、p53 protein and PCNA expressions were detected in 30 specimans of pancreatic carcinoma and 3 samples of normal pancreatic tissue by the method of immunohistochemistry.The data were analyzed in connection with clinical findings. Results p21 protein and p53 protein expressions showed positive correlation in pancreatic carcinoma and positive expression rates are 75% and 53.33% respectively;The positive expression rate of PCNA is 43.33%±17.99%,with the exacerbation of pancreatic cancer in increases and is positively correlated with prognosis and p53 expression (P<0.05). Conclusion The occurrence and development of pancreatic cancer are the result of associated function for many oncogene and antioncogene;PCNA is an indicator to judge malignant degree and prognosis of pancreatic cancer.
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