Abstract: Objective 　To investigate the possible relationship between the expressions of TGF-β1 and CD105 in human gliomas and clinical significance. Methods 　The expressions of TGF-β1 and CD105 were examined by SP Immunohistochemical staining in 70 human glioma specimens and in 10 normal human brain tissue specimens, and their relationship s with clinic-pathological factors was also analyzed. Results The expressions of TGF-β1 and CD105 were closely associated with pathological grade ( P < 0. 01), but theirs expression in gliomas had no obvious relationship to the sexes, ages and sizes of tumor ( P > 0. 05) .The MVD values (37. 68 ±4. 91) in TGF-β1 positive groups was significantly higher than those (30. 01 ±5. 26) in negative groups ( P < 0. 01), and The expressions of TGF2β1 and CD105 were positively correlated ( r = 0. 6547, P < 0. 05) . Conclusion 　The cojioned overexpressions of TGF-β1 and CD105 may promote malignant proliferation and angiogenesis of glioma.