热休克蛋白gp96在喉癌中的表达及临床意义

Significance of Heat Shock Protein gp96 Expression in Laryngeal Squamous Carcinomas

摘要: 目的检测热休克蛋白gp96在喉癌中的表达,并探讨其在喉癌发生发展中的作用。方法应用免疫组织化学方法检测46例喉癌组织热休克蛋白gp96的表达。结果T1~2期喉癌患者癌组织与T3~4期患者比较,T1~2gp96表达的阳性百分率较高,其差异有显著性意义(P<0.05)。病理学Ⅰ级患者与病理学Ⅱ~Ⅲ级患者比较,Ⅰ级患者癌组织gp96表达的阳性百分率较高,其差异有显著性意义(P<0.05)。有颈淋巴结转移的患者gp96表达的阳性百分率明显低于无颈淋巴结病理转移的患者(P<0.01)。热休克蛋白gp96阳性表达与患者年龄(P=0.680)、性别(P=0.888)、吸烟史(P=0.819)、肿瘤生长部位(P=0.580)无相关性。结论热休克gp96的表达与喉癌的发生发展密切相关,其表达可以作为判断预后的参考指标之一。

Abstract: Objective To study the expression and clinical significance of heat shock protein gp96 in laryngeal squamous carcinomas. Methods The expression of gp96 protein in 46 laryngeal squamous carcinomas was detected by immunohistochemical staining and its correlations with clinicalpathological factors were analyzed. Results The expression of gp96 in laryngeal squamous carcinomas of the group T_ 1~2 was stronger than that in the group T_ 3~4 . There was remarkable difference between the two groups(P< 0.05 ). The...