Abstract: Objective To study the clinical significance of expression of VEGF in non-small-cell lung cancer (NSCLC). Methods By using SP immunohistochemical method with anti-VEGF multiclonal antibody,we detected the expression of VEGF in 65 cases NSCLC and studied the correlation between expression of VEGF and pathological types,lymph node metastases,the size of tumor mass and clinical stages. Results The total positive rate (78.5%)of VEGF expression in NSCLC was much higher than that(3.1%)in the nomal tissues nearby.VEGF expression was associated with the size of tumor mass (P<0.05),but had no association with pathological types,lymph node metastases or the desease staging. Conclusion The data demonstrated that expression of VEGF might be used as an objective indicator of the extent of invation and the prognosis in NSCLC.