非小细胞肺癌细胞凋亡及Fas/FasL表达的关系

doi:10.3971/j.issn.1000-8578.3408

非小细胞肺癌细胞凋亡及Fas/FasL表达的关系

Relationship between Apoptosis and Fas/FasL Expression in Non-small Cell Lung Carcinoma

摘要

摘要: 目的　探讨凋亡相关基因Fas/FasL表达与非小细胞肺癌细胞凋亡和临床病理特征的关系。方法　采用免疫组织化学和脱氧核糖核苷酸末端转移酶介导的缺口末端标记(TUNEL)技术对45例肺癌和38例癌旁组织中的Fas和Fasl表达及凋亡细胞水平进行检测。结果　与癌旁组织比较，肺癌中FasL表达增加，Fas表达降低，凋亡细胞减少；FasL表达与组织类型有关；肺癌细胞凋亡水平在淋巴结转移和晚期癌组织中明显受抑；Fas表达阳性的凋亡细胞指数明显高于Fas表达阴性组。结论　细胞凋亡调控异常在肺癌发病中可能起重要作用。

Abstract: Objective To study Fas/FasL expression in non-small cell lung carcinoma(NSCLC)and its association with apoptosis and clinicopathological characteristics. Methods Fas and FasL protein expression and apoptotic cells in situ in 45 NSCLC and 38 paracancerous tissues were detected using immunohistochemical staining and terminal deoxynucleotidyl transferase mediated nick end labeling(TUNEL)technique. Results The AI in NSCLC was significantly lower than that in paracancerous tissues,and the AI of NSCLC was closely related to lymph node metastasis and TNM stages,but no close relation was observed among histological types,cell differentation and sex,age of patients.The AI in the Fas positive group was higher than that in the Fas negtive group. Conclusion The abnormal regulation of apoptosis may play an important role in the pathogenesis of NSCLC.

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