Abstract: Objective 　To investigate the change of cytokines in plasma af ter int ravenous chemotherapy in patient s with digestive t ract cancer and to discuss it s clinical significance. Methods 　Using EL ISA meth2 od, we assessed the change of cytokines in plasma in patient s with digestive t ract cancer af ter chemother2 apy. Results 　Cytokines in plasma in patient s with digestive t ract cancer showed that the concent ration of IL22 was decreased with statistical significance in patient s with digestive t ract cancer compared with nor2 mal person, while the concent ration of IL210 and TNF2αcould be higher than those of normal person and without statistical significance. All the variations were related with clinical stage of tumor. One week af2 ter int ravenous chemotherapy in effective patient s with advanced digestive t ract cancer, the concent ration of IL22 was significantly decreased ; two weeks later, the concent ration of IL22 was recovered and closed to normal level ; three weeks later, it was even higher than the concent ration before chemotherapy. IL22 of patient s in non2effective group was slightly increased af ter chemotherapy but still lower than before. All the variations of IL210 and TNF2α af ter chemotherapy were showed the t rend declined af ter rising first . Conclusion 　Patient s with advanced2stage cancer have a poor immune response which was related with clinical stages of tumor. Af ter int ravenous chemotherapy, in early stage (about 122 weeks) patient s were both in an immunosuppressant state. While three weeks later, patient s with different result s showed different immune states. It may be followed by“rebound2overshoot”recovery of immune function in patient s with favorable clinical course.