DDIT3在甲状腺滤泡型良恶性肿瘤中的表达及意义

Expression and Significance of DDIT3 in Benign and Malignant Follicular Thyroid Tumors

摘要: 目的探讨DDIT3在甲状腺良恶性滤泡型肿瘤中的表达及意义。方法采用免疫组化Envision法检测24例滤泡性腺瘤、44例滤泡癌中DDIT3的表达情况。结果DDIT3在甲状腺滤泡性腺瘤、滤泡癌中的表达率分别为20．8％和93．2％，两者比较差异有统计学意义（P〈0．001）。同时观察10例甲状腺滤泡癌癌旁组织，DDIT3不表达或表达甚少。结论DDIT3可作为鉴别甲状腺滤泡癌和滤泡性腺瘤的一个较有价值的指标。

Abstract: Objective 　To investigate the expression and significance of DNA damage2inducible t ranscript 3 (DDIT3) in benign and malignant follicular thyroid tumors. Methods 　The expression of DDIT3 in 24 ca2 ses of follicular thyroid adenoma ( FTA) and 44 cases of follicular thyroid carcinoma ( FTC) was detected by immunohistochemist rical Envision method. Results 　The positive rates for DDIT3 in FTA and FTC were 20. 8 % and 93. 2 % respectively, there was significant difference between them ( P < 0. 001) . More2 over, 10 cases of paracarcinomatous tissue were observed, there was no or week expression of DDIT3. Conclusion 　DDIT3 may be used as a marker for differentiating FTC and FTA.