奈达铂联合替加氟治疗晚期食管癌的临床观察

doi:10.3971/j.issn.1000-8578.3340

奈达铂联合替加氟治疗晚期食管癌的临床观察

Short-term Effects of Nedaplatin Plus Futraful Chemotherapy in Treatment of Advanced Esophageal Carcinoma

摘要

摘要: 目的探讨奈达铂（NDP）＋替加氟（FT-207）方案治疗晚期食管癌的近期疗效和毒副作用。方法观察组为NDP／FT-207，方案：NDP80～100mg／m^2，静滴，第1天，FT-207 500-600mg／m^2，静滴，第1～5天，每28天为1个周期，2～3周期为1个疗程，对照组为DDP／5-Fu，方案：DDP80～100mg／m^2，静滴，第1天，5-Fu500-750mg／m^2，静滴，第1～5天，每28天为1周期，2～3周期为1个疗程。结果全部病例均可评价疗效及不良反应，其中NDP／FT-207方案治疗42例，有效率为57．1％，DDP／5-Fu方案治疗36例，有效率为50％，两组有效率差异无统计学意义，消化道反应及骨髓抑制等毒副反应观察组较对照组明显减轻（P〈0．05）。结论奈达铂联合替加氟治疗晚期食管癌近期疗效与DDP／5-Fu方案相近，但毒副作用明显减轻。

Abstract: Objective 　To observe the efficacy and the side effect s of nedaplatin with fut raful in the t reat2 ment of advanced esophageal carcinoma. Methods 　Observing group NDP/ FT2207 regiment : given neda2 platin 80～100 mg/ m2 on day 1and fut raful 500～600 mg/ m2 on day 1 to 5 ; cont rol group :DDP/ 52Fu reg2 iment received cisplatin 80～100 mg/ m2 on day 1and 52Fluorouracil 500～750 mg/ m2 on day 1 to 5. In both groups per 28 days was a cycle, 2～3 cycles were one course. Results 　Response and toxicity could be assessed in all the 78 patient s, 42 patient s were in observing group, the other 36 patiest s were in con2 t rol group. The response rate of patient s t reated by NDP/ FT2207 and DDP/ 52Fu were 57. 1 % (24/ 42) and 50 % (18/ 36) respectively. The two groups have no significant difference. Conclusion 　The side effect s as gast rointestinal reactions and myelosuppression etal in observing group is lighter than that in cont rol group.

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