Abstract: Objective 　To compare the advantage and disadvantage between peripherally inserted central catheter ( PICC) and internal jugular venous catheter. Methods 　The patient s were divided into two groups by different insertion methods. The success rate of insertion, manipulatory and intubalation time, fluid speed, complication incidence were compared. Results 　Compared with internal jugular venous catheter, PICC had a higher rate of successful insertion, was 88. 2 %( P < 0. 05), a less time of insertion, average worker time 13. 38 ±5min ( P < 0. 01), a longer time of intubalation, average 128 day ( P < 0. 01) .The main complications of PICC were catheter occlusion, phlebitis and catheter related infection. The main complications of internal jugular venous catherer related infection and artery damage. Conclusion 　Both routes of cent ral venous catheterization had advantage and disadvantage. PICC was safer and easier to place, and it was the first choice for long-time chemotherapy had iv therapy. Careful manipilation and nursing should be practiced for both routes to decrease the rate of cmpmplications.