放射治疗配合全身化疗治疗局部晚期鼻咽癌
Radiation therapy combined with chemotherapy for locally advanced nasopharyngeal carcinoma
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摘要: 目的 评价放化结合和单独放疗治疗局部晚期鼻咽癌的疗效和毒副反应。方法 将 4 3例鼻咽癌随机分为放化组和单放组。结果 全组 1、3年生存率分别为 88.4 %和 5 1.2 %, 放化组和单放组的 1年生存率分别为 90 .5 %和 86 .4 % (P >0 .0 5 ), 3年生存率分别为 5 7.1%和 4 5 .5 % (P >0 .0 5 )。放化组的主要毒副反应为恶心、呕吐和白细胞下降, 发生率分别为 90 .5 %和 10 0 %, 均为Ⅰ～Ⅲ度。结论 研究结果显示POB联合化疗合并放射治疗晚期鼻咽癌是可以耐受的, 对改进鼻咽癌的治疗效果仍有待进一步研究Abstract: Objective To compare the result and side-effect of radiation therapy combined with chemotherapy(CRT) and radiation therapy alone(RT) for locally advanced Nasopharyngeal Carcinoma. Mehods 43 patients with for locally advanced nasopharyngeal carcinoma were radomized into two groups:21 entred in the CRT and 22 in the RT group. Results The survival rates of all the patients at 1 and 3-year were 88.4%,51.2%. The survival rates at 1 and 3-year were 90.5%, 57.1% in the CRT group and86.4%, 45.5% in the RT gro...
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