DF方案加放疗治疗晚期鼻咽癌疗效观察

DF protocd plus radiotherapy in treatment of patients with advanced nasopharyngeal carcinoma

摘要: 目的　观察DF方案加放疗治疗晚期鼻咽癌的临床疗效。方法　 1994年 3月至 1997年 10月, 对36例Ⅲ、Ⅳa期鼻咽癌患者治疗用DF方案化疗加放疗, 并与同期行单纯放疗的 2 8例患者进行对比分析。结果　化放组和单放组鼻咽肿瘤完全消退率分别为 91.7%和 85 .7% (P >0 .0 5 ) ;颈部转移淋巴结完全消退率分别为 6 3.9%和 5 0 % (P >0 .0 5 ) ;两组 3年生存率分别为 6 3.9%和 4 6 .4 % (P >0 .0 5 ) ;5年生存率分别为 6 1.1%和35 .7% (P <0 .0 5 ) ;5年鼻咽部肿瘤控制率分别为 6 6 .7%和 39.3% (P <0 .0 5 ) ;5年发生远处转移率分别为 2 5 %和 5 0 % (P <0 .0 5 )。结论　DF方案化疗和尽早放疗的综合治疗能提高晚期鼻咽癌生存率, 局控率和减少远处转移

Abstract: Objective This study is to evaluate the effect of chemotherapy combined with radiotherapy for the treatment of the patients with advanced nasopharyngeal carcinoma(NPC). Methods Fom march 1994 to October 1997,64 patients with stage Ⅲ, Ⅳa NPC ( 92 stage system)at random received one course of chemotherapy of DF protocol (5-FU and cisplatin) before radiotherapy (which started 3 days after the firstcycle of chemotherapy) and two to three cycles ofpost-radiotherapy chemotherapy or radiotherapy alone (includin...