化疗联合不同剂量放疗治疗中晚期非小细胞肺癌

Chemotherapy Combined with Different Dosage Radiotherapy in Treatment of Local and Advanced Non-small Cell Lung Cancer

摘要: 目的　探讨化疗加低剂量放疗综合治疗中晚期非小细胞肺癌的方法、疗效、预后及其副反应。方法　回顾性分析 6 8例经病理确诊为非小细胞肺癌患者资料, 根据所接受的放疗剂量不同分成。治疗组 (化疗 +低剂量放疗 ) 33例和对照组 (化疗 +根治剂量放疗 ) 35例。两组均用CEP化疗方案, 放疗剂量, 其中治疗组 4 5Gy, 对照组 ( 6 0～ 70 )Gy。结果　治疗组 1,2, 3,4年生存率分别为 6 1%, 2 1.2 %, 9.1%, 9.1% ;对照组 1,2, 3,4年生存率分别为 85 .7%, 11.4 %, 2 .86 %, 0 %, 两组生存率比较, 1年生存率有显著性差异 (P <0 .0 5 ), 2、3、4年生存率无显著性差异 (P >0 .0 5 ) ;骨髓抑制及放射性肺损伤两组比较差异存在显著性 (P <0 .0 5 )。结论　CEP方案化疗加低剂量放疗综合治疗中晚期NSCLC可明显减轻毒副作用、提高生活质量同时不减少生存时间

Abstract: Objective To evaluate the technique, effect, prognosis and side effects of chemotherapy combined with low dosage radiotherapy for patients with local and advanced non small cell lung cancer. Methods From July 1989 to July 2001, a total 68 patients with pathologically confirmed non small cell lung cancer were retrospectively analyzed. According to the different dosage radiotherapy, the patients were divided into treatment group(chemotherapy plus low dosage mdiotherapy) and control group(chemotherapy plu...