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大分割三维适形放疗联合化疗治疗Ⅲ期非小细胞肺癌疗效分析[J]. 肿瘤防治研究, 2004, 31(08): 498-500. DOI: 10.3971/j.issn.1000-8578.3173
引用本文: 大分割三维适形放疗联合化疗治疗Ⅲ期非小细胞肺癌疗效分析[J]. 肿瘤防治研究, 2004, 31(08): 498-500. DOI: 10.3971/j.issn.1000-8578.3173
Three Dimensional Conformal Hypofractionated Hige-dose Radiotherapy Combined with Chemotherapy for Stage Ⅲ Non-small-cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2004, 31(08): 498-500. DOI: 10.3971/j.issn.1000-8578.3173
Citation: Three Dimensional Conformal Hypofractionated Hige-dose Radiotherapy Combined with Chemotherapy for Stage Ⅲ Non-small-cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2004, 31(08): 498-500. DOI: 10.3971/j.issn.1000-8578.3173

大分割三维适形放疗联合化疗治疗Ⅲ期非小细胞肺癌疗效分析

Three Dimensional Conformal Hypofractionated Hige-dose Radiotherapy Combined with Chemotherapy for Stage Ⅲ Non-small-cell Lung Cancer

  • 摘要: 目的 探讨大分割三维适形放疗 ( 3DCRT)联合化疗治疗Ⅲ期非小细胞肺癌 (NSCLC)的疗效和毒副反应。方法 对 98例Ⅲ期NSCLC患者进行同期放化疗 :紫杉醇 4 0mg/m2, 卡铂 (AUC =2 ), 每周 1次, 共 6周。 3DCRT从第 2周开始, 6~ 8Gy/次, 隔日一次, 总剂量 6 0~ 6 6Gy, 2 0~ 2 4d完成。上述治疗后再进行两周期化疗 :紫杉醇 135mg/m2, 卡铂 (AUC =5 ), 第 1天, 2 1天为 1周期。结果  98例患者全部完成治疗, 肿瘤完全缓解 (CR) 30 .6 1%, 部分缓解 (PR) 5 2 .0 4 %, 总有效率 (CR +PR) 82 .6 5 %。纵隔转移淋巴结CR 36 .4 %, PR 6 3.6 %, 总有效率 10 0 .0 %。 1、2年生存率分别为 77.5 5 %、5 6 .12 %。白细胞下降发生率 94 .88%, 其中Ⅲ、Ⅳ度白细胞下降 4 7.96 % ;2 9.5 9%出现Ⅱ~Ⅲ级血小板减少 ;放射性食管炎发生率 4 4 .89%, 其中 7.14 %为Ⅲ级放射性食管炎。放射性肺炎发生率为 11...

     

    Abstract: Objective To explore the curative effects and side effects of three dimensional conformal hypofractionated hige dose radiotherapy(3DCRT) combined with chemotherapy for stage Ⅲ non small cell lung cancer(NSCLC). Methods 98 patients with Stage Ⅲ NSCLC were treated with 3DCRT and chemotherapy concurrently: Paclitaxel 40mg/m 2, Carboplatin AUC=2, once a week, 6 weeks totally; 3DCRT began from the second week at the total dose of 60~66Gy in a course of 20~24 days, 6~8Gy for each fraction. After that, two cy...

     

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