uPA和VEGF在脑星形细胞瘤侵袭中的作用及其相关性的研究
Role of Urokinase-type Plasminogen Activator and Vascular Endothelial Growth Factor and the Correlation in Human Astrocytomas Invasion
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摘要: 目的 探讨尿激酶型纤溶酶原激活剂 (uPA)和血管内皮细胞生长因子 (VEGF)在人脑星形细胞瘤中的表达特征及意义。方法 用免疫组化的方法检测uPA和VEGF在 6 4例星形细胞瘤、4例垂体腺瘤、5例正常脑组织中的表达情况。结果 6 4例星形细胞瘤中均有uPA和VEGF的表达, 且随恶性程度的升高, 其表达也随之升高。在垂体腺瘤中低度表达, 在正常脑组织中无表达。uPA和VEGF在星形细胞瘤中的表达呈正相关 (r =0 .92 )。结论 uPA和VEGF的表达与星形细胞瘤的侵袭性和血管的生成等有关。uPA和VEGF在星形细胞瘤中的表达具有协同性Abstract: Objective To investigate the expression features and clinical significance of urokinse-type plasminageon activator and vascular endothelial growth factor (uPA) in human astrocytomas. Methods We retrospectively studied the presence and distribution of uPA and VEGF protein by immunohistochemical method in 64 cases of human brain astrocytomas、4 cases of pituitary adenoma、5 cases of normal brain tissue.Their relation to clinical data was also comparatively analyzed. Results All astrocytomas expressed uPA and V...
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