初发及复发转移大肠癌组织与外周血MDR-1基因表达相关性研究
The relationship between the expression of MDR-1 in carcinoma tissue and in extroperiblood of primary and recurrent metastatic adenocarcinoma of colon and rectum
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摘要: 目的 探讨初发及复发转移大肠癌组织与外周血MDR 1基因表达的相关性。方法 采用RT PCR方法分别检测了 5 6例初发大肠癌组织及外周血和 4 0例术后化疗的复发转移大肠癌病灶组织及外周血的MDR 1表达情况。结果 无论是组织中, 还是外周血中经过化疗的大肠癌患者MDR 1的阳性表达率均明显高于初发大肠癌患者, 统计学上有显著性差异 (P <0 .0 5 )。结论 可以用外周血代替癌组织来检测MDR 1基因的表达Abstract: Objective To explore the relationship between the expression of MDR-1 gene in carcinoma tissue and in extroperiblood of primary and recurrent metastatic adenocarcinoma of colon and rectum. Methods Detect the expression of MDR-1 in carcinoma tissue and extroperiblood of 50 cases of primary and 40 cases of recurrent of metastatic adenocarcinoma of colon and rectum after surgical resection by RT-PCR respectively. Results Whether in tissue or in extroperiblood, those treated by chemotherapy have significant...
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