非小细胞肺癌神经内分泌分化的检测及意义

Detection and its significance of the neuroendcrine differentiation in non-small cell lung carcinoma

摘要: 目的　探讨非小细胞肺癌 (NSCLC)的神经内分泌 (NE)分化状况、免疫组化检测指标及其意义。方法　采用SP免疫组化法检测 113例NSCLC中神经元特异性烯醇化酶 (NSE)、突触素 (SYN )和嗜铬素A(CgA)的表达。结果　NSCLC中NSE、SYN、CgA的阳性率分别为 5 3.10 %、2 6 .5 5 %、6 .19%, NSE与SYN联合检测, 其阳性率为 2 1.2 4 %。 3种NE标记物在不同组织学类型NSCLC中的表达无显著性差异。SYN阳性率随肿瘤分化程度降低而增高。NSE与SYN、SYN与CgA表达之间显著相关。结论　NSCLC的NE分化与组织学类型无关, 与分化程度有关。NSE和SYN联用是判断NE分化的较好指标

Abstract: Objective To study differentiation of neuroendocrine(NE)in non-small cell lung carcinoma (NSCLC)and its immunohistochemical markers and their significance. Methods NSCLC from 113 patients were analyzed immunohistochemically with antibodies to neuro-specific enolase(NSE),synaptophysin(SYN)and chromogranin,(CgA). Results The following percentages of cases were positive for each marker: NSE, 53.10%; SYN, 26.55%; CgA, 6.19%; NSE and SYN, 21.24%. There was no relationship between the expression of three marke...