希罗达+伯尔定结合同期放疗治疗老年晚期鼻咽癌的临床体会
Concurrent Chemoradiotherapy Using Oral Capecitabine and Carboplatin in the Treatment of Elderly Patients with Advanced Nasopharyngeal Carcinoma
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摘要: 目的探讨同期放化疗对老年晚期鼻咽癌患者治疗的安全性和有效性。方法从2002年7月~2005年7月,25例初诊60岁以上的老年局部晚期(III、IV期)鼻咽癌病人接受了希罗达和伯尔定化疗和同期放疗。化疗方法为希罗达750~850mg/m2,每天2次口服,第1~14天,伯尔定(AUC=6mg/min)静脉注射,第1天,3周为1个疗程,共2个疗程。放射治疗于第2程化疗的第1天开始,给予常规分割根治性放疗。结果25例病人均可评价疗效和毒性反应。总有效率(OR)100%,临床完全缓解(CR)22例(88%)。18例(72%)病人出现III度口腔粘膜炎,4例(16%)III度放射性皮炎,无治疗相关死亡。结论初步结果显示对于老年晚期鼻咽癌病人,希罗达+伯尔定同期放化疗是一个安全方便、耐受良好且疗效高的治疗方法,值得临床推广应用。Abstract: Objective To investigate the efficacy and tolerability of Concurrent chemoradiotherapy in the treatment of elderly patients with advanced nasopharyngeal carcinoma. Methods Between July 2002 and July 2005,25 Patients aged over 60 years with locally advanced nasopharyngeal carcinoma received concurrent chemoradiotherapy.Chemotherapy consisted of 2 cycles oral capecitabine (750～850mg/m2 twice daily) on day_ 1-14 and i.v.carboplatin (AUC=6mg/min) on day_ 1 .The cycle was repeated every 3 weeks.Radiation with s...
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