Abstract: Objective 　To evaluate the efficacy and toxicity of a combination of gemcitabine and cisplatin in elderly patient s with advanced cancer, the clinical benefitial response. Methods 　Gem 800 mg/ m2 ivdrop d1, 8, 15 ;DDP 30 mg/ m2 iv drop d2～4, each cycle lasted for 28 days, at least for 2 cycles. Results 　Sixty four patient s were evaluated with 46. 9 %, twenty2eight patient s of NSCLC were evaluated with 46. 4 %, eighteen patient s of pancreatic cancer were evaluated with 44. 4 %, eighteen patient s of breast cancer were evaluated with 50. 0 %. Median survival time and TTP was 11 months and 6. 2 months, the curative effect included easement of pain, obviously improvement of general state, better quality of exist2 ence and increased KPS score. The main adverse effect s were bone marrow depression, nausea, vomitting and so on. There was no t reatment related death. Conclusion 　The elderly patient s with advanced cancer t reated with GP regimen may obtain high remission rate and low toxicity and better tolerated alternative and represent s an option for the t reatment of the elderly patient s with advanced cancer.