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早期宫颈癌患者细胞免疫功能的改变[J]. 肿瘤防治研究, 2000, 27(05): 373-374. DOI: 10.3971/j.issn.1000-8578.2761
引用本文: 早期宫颈癌患者细胞免疫功能的改变[J]. 肿瘤防治研究, 2000, 27(05): 373-374. DOI: 10.3971/j.issn.1000-8578.2761
Alterations of Cell Immune Functions of the Patients with Cervical Cancer in Early-stage[J]. Cancer Research on Prevention and Treatment, 2000, 27(05): 373-374. DOI: 10.3971/j.issn.1000-8578.2761
Citation: Alterations of Cell Immune Functions of the Patients with Cervical Cancer in Early-stage[J]. Cancer Research on Prevention and Treatment, 2000, 27(05): 373-374. DOI: 10.3971/j.issn.1000-8578.2761

早期宫颈癌患者细胞免疫功能的改变

Alterations of Cell Immune Functions of the Patients with Cervical Cancer in Early-stage

  • 摘要: 目的 了解早期宫颈癌病人的细胞免疫功能变化,并探讨其与肿瘤大小、病理类型、病理分级、淋巴结转移、脉管瘤栓的关系。方法 采用FCM方法检测63例早期宫颈癌病人外周血中NK细胞及T淋巴细胞亚群的百分比,并采用60例正常人群作对照。结果 早期宫颈癌病人的外周血中NK细胞的百分比,显著低于正常人(P<0.01),CD4细胞百分比低于正常人群(P<0.05),CD4/CD8比值显著低于正常人群(P<0.01),CD8细胞百分比高于正常人群(P<0.05),且与肿瘤大小、淋巴结转移的数目及脉管瘤栓有关,与肿瘤的病理类型、分级无关。结论 早期宫颈癌病人的细胞免疫功能较正常人低,局部肿瘤越大,有淋巴结转移或脉管瘤栓,则病人的免疫功能越低,为临床上了解早期宫颈癌病人的细胞免疫功能、估计预后提供参考。

     

    Abstract: Objective To study the alterations of cell immune functions of the patients with cervical cancer in early-stage and to research the relationship between the alterations and size of tumors, histological types and grades,metastasis of lymph node and lymphvascular invasion. Methods To test percent rate of NK cells and Tlymphocyte subset of 63 patients with cervical cancer in early,the healthy people were chosen as controls. Results In the peripheral blood of the patients with early-staged cervical cancer,Percent-rates of NK and CD4 Cells were very lower than that of the healthy people respectively.The rate of CD4/CD8 was much lower than that of the healthy people.Percent rate of CD8 cells was higher than that of the healthy people.The alterations of cell immune functions were related to the size of the tumors,metastasis of lymph node and lymph-vascular invasion,which were not related to the histological types and grades of the tumors. Conclusion The cell immune functions of the patients with early-staged cervical cancer were low.The larger the tumors were,the lower the cell immune functions of the patients with cervical cancer in early were.

     

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