乳腺癌PCNA表达与肥大细胞密度的关系

doi:10.3971/j.issn.1000-8578.2706

乳腺癌PCNA表达与肥大细胞密度的关系

The Relationship of PCNA Expression and MC Density in the Breast Cancer

摘要

摘要: 目的　探讨乳腺癌组织中PCNA表达与MC密度的关系。方法　用免疫组织化学方法和俾士麦棕法分别检测100例乳腺癌组织中增殖细胞核抗原(PCNA)和肥大细胞(MC)。结果　1.PCNA阳性表达与乳腺癌分化程度和淋巴结转移相关，高分化癌阳性表达低于中分化癌和未分化癌，P<0.05；淋巴结有转移者PCNA阳性表达高于无转移者，P<0.01。2. PCNA阳性者，MC计数较低；PCNA阴性者，MC计数较高，乳腺癌PCNA表达与癌周MC密度呈负相关。结论　PCNA是判断乳腺癌预后的有效指标，MC可能通过影响PCNA的表达发挥其抗肿瘤作用。

Abstract: Objective To investigate the relationship of PCNA expression and MC density in the tissues of breast cancer. Methods Immunohistochemical method and Bismark brown staining were used respectively for the observation of proliferating cell nuclear antigen (PCNA) and mast cell(MC). Results 1.PCNA positive expression were correlation with breast cancer differentiated degree and lymph metastases. High differentiated cancer positive expression were lower than mediated and undifferentiated cancer,P<0.05;PCNA positive expression with lymph metastases were higher than without lymph metastases,P<0.01. 2.As for MC counts PCNA positive cases were lower than PCNA negative ones,PCNA positive expression were negatively correlated with MC density around cancer. Conclusion PCNA were a good prognostic factor of breast cancer,MC gave play to their anti-tumour effects probably through influencing PCNA expression.

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