p53、bcl-2蛋白和p-gp在鼻咽鳞癌中表达的研究
Expressions of p53、bcl-2 Proteins and p -glycoprotein Nasopharyngeal Squamous Cell Carcinoma
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摘要: 目的 研究 p5 3、bcl 2蛋白和 p gp在鼻咽鳞癌组织中的表达及其临床病理特征的关系, 探讨其在预后评估中的意义。方法 采用免疫组化SP法检测 6 4例鼻咽鳞癌组织中p5 3、bcl 2和 p gp的表达。结果 鼻咽鳞癌组织中 p5 3、bcl 2和p gp阳性率分别为76 .5 6 % (4 9/ 6 4 )、89.0 6 % (5 7/ 6 4 )、17.19% (11/6 4 )。p5 3、bcl 2蛋白过表达均与颈部淋巴结转移、组织分化程度有关 (P <0 .0 1)。p gp过表达与bcl 2蛋白过表达呈正相关 (P <0 .0 5 ), p5 3蛋白过表达与bcl 2蛋白过表达呈正相关 (P <0 .0 0 1)。结论 p5 3和bcl 2蛋白均参与鼻咽鳞癌的发生与分化, 其表达水平的不同有助于预后判断 ;未经治疗的鼻咽鳞癌存在原发性耐药Abstract: Objective To investigate the p53、bcl 2 proteins and p glycoprotein(p gp) expression in the patients with nasopharyngeal squamous cell carcinoma(NPSC) and their relations to clinical pathological features. Methods 64 specimens with NPSC were detected by immunohistochenmical technique SP for p53、bcl 2 and p gp. Results The positive expression rates for p53、bcl 2 and p gp were 76.56% (49/64)、 89.06% (57/64)、 17.19% (11/64),respectively.A significantly correlation was found that both bcl 2 and...
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