两种方案预防化疗引起延迟性呕吐的临床对比观察

Comparison of a Sulpiride-based and a Metoclopramide based Combination in the Prevention of Delayed Emesis Induced by Chemotherapy

摘要: 目的　通过与甲氧氯普胺联合地塞米松 (B方案 )进行对比, 观察舒必利联合地塞米松 (A方案 )预防化疗所致延迟性恶心呕吐的疗效和不良反应。方法　采用临床随机自身对照方法, 将 4 7例接受含顺铂或阿霉素联合化疗的患者随机分为AB、BA两组。行两个周期相同方案的化疗 :AB组第 1周期用A方案, 第 2周期B方案 ;BA组第 1周期用B方案, 第 2周期用A方案。结果　A方案对延迟性恶心和呕吐的完全控制率分别为 6 1.7%和 6 6 .0 %, B方案对延迟性恶心和呕吐的完全控制率分别为 5 3.2 %和6 8.1%。两组控制率及不良反应的差别无统计意义。结论　舒必利联合地塞米松对延迟性呕吐的预防效果好, 其不良反应轻微

Abstract: Objective To compare the efficacy and adverse effects of a sulpiride based and a metoclopramide based combination in the prevention of delayed emesis induced by chemotherapy. Methods In a clinical randomized controlled cross over trial, 47 patients treated with regimens containing cisplatin or adriamycin were randomized into AB and BA group. In group AB, sulpiride combined with dexamethasone was given in the first cycle and metoclopramide combined with dexamethasone in the second cycle, while in group B...