鼻咽癌DNA含量与临床某些特征的研究
Study on Correlations between DNA Contents and Some Clinical Features in Patients of Nasopharyngeal Cancer
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摘要: 目的 分析鼻咽癌病人DNA含量与临床某些特征的关系。方法 对 89例病理诊断为鼻咽癌肿瘤标本, 用图像仪进行检测。结果 鼻咽癌异倍体病人为 2 5人, 占 2 8% (2 5 /89) ;二倍体病人为 6 4人, 占 72 % (6 4 /89)。肿瘤细胞DNA含量与病人的病期、淋巴结转移、颅底骨和颅神经是否受累无关 ;但与颅底骨和颅神经同时受累有关, 与生存率也有关。颅底骨、颅神经同时受累其异倍体率较单一颅底骨或颅神经受累者高, 分别为 4 2 %和 16 % (P =0 .0 2 3), 5年存活病人异倍体率较 2年存活病人低, 分别为12 %和 2 8% (P =0 .0 2 9)。结论 异倍体鼻咽癌侵犯性强, 长期生存率低Abstract: Objective To find the correlations between DNA contents and some clinical features in NPC. Methods 89 samples from patients of NPC diagnosed pathologically were studied by the image cytometry. Results The patients of NPC with aneupoid and diploid were 25 and 64, which occupied 28% and 72% in all cases, respectively. DNA content of tumor cell in NPC had no xetations with clinical stage, lymph nodes and the involvement of base of skull and cranial nerve. But it was related to the both involvements of cranial n...
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