谷胱甘肽硫转移酶M1基因多态和吸烟与贲门癌易感性关系研究

Relationship between Glutathione S-transferase M1 Genetic Polymorphisms and Cigarette Smoking and Susceptibility of Cardial Carcinoma

摘要: 目的　探讨谷胱甘肽硫转移酶M 1(GSTM1)基因多态和吸烟与贲门癌易感性关联。方法　GSTM1基因多态性用多重PCR技术检测。结果　GSTM 1空白基因型在贲门癌组 (6 2 .5 % )、低分化贲门癌组 (6 9.2 % )与对照组 (4 6 .5 % )之间的频率差异均有显著性 (P <0 .0 5 )。GSTM1空白基因型在重度吸烟的贲门癌组 (75 .0 % )与对照组 (4 7.1% )之间的频率差异有显著性 (P <0 .0 5 )。结论　GSTM1空白基因型与贲门癌遗传易感性有关, 肿瘤多呈低分化腺癌 ;重度吸烟可显著提高GSTM1空白基因型个体患贲门癌的危险性

Abstract: Objective In this study, we analyzed the association cigarette smoking,glutathione S transferase M1(GSTM1) genetic polymorphisms with susceptibility of cardial carcinoma. Methods The genetic polymorphisms of the GSTM1 gene of 114 healthy people and 72 cardial carcinoma patients were studied byusingmultiplex PCR. Results The difference of frequency of GSTM1 null genotype between patients(62.5%) and the controls ( 46.5% ) was statistically significance ( P < 0.05 ), the GSTM1 null genotype was sig...