肝细胞癌VEGF 、bFGF 与凋亡相关蛋白表达的关系

doi:10.3971/j.issn.1000-8578.2475

肝细胞癌VEGF 、bFGF 与凋亡相关蛋白表达的关系

Correlation between the Expressions of VEGF, bFGF and Some Apoptosis Proteins in Hapatocellular Carcinoma

摘要

摘要: 目的探讨肝细胞癌(hepatocellular carcinoma，HCC)组织中血管内皮生长因子(vascular endothelial growth factor，VEGF)、碱性成纤维细胞生长因子(basic fibroblast growth factor，bFGF)以及凋亡相关蛋白Fas、bax、bcl-2和bcl-xl之间的关系。方法对经病理证实的肝细胞癌38例共40个癌灶进行分析，用免疫组化SP法检测癌组织中VEGF、bFGF、Fas、bax、bcl-2和bcl-Xl的表达情况，分析它们之间的相互关系。结果 VEGF、bFGF、Fas、bax、bcl-2和bcl-xl的阳性表达率分别为77．5％(31／40)、75％(30／40)、20％(8／40)、25％(10／40)、27．5％(11／40)和50％(20／40)。VEGF与bFGF、bcl-2与bcl-xl之间明显相关(P<0．01)，bax与bcl-2、VEGF与bcl-2、bax与bFGF之间也存在一定的相关性(P<0．05)。结论 VEGF、bFGF和凋亡相关蛋白共同调控HCC的血管生成和细胞凋亡。

Abstract: Objective 　To explore the correlation between the expressions of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and some apoptosis proteins including Fas, bax, bcl-2 and bcl-xl in hepatocellular carcinoma ( HCC) . Methods 　Thirty2eight cases (40 lesions) of HCC verified by histopathology were studied. The expressions of VEGF, bFGF, Fas, bax, bcl-2 and bcl-xl were detected with immunohistochemical SP method, and the relationships among these proteins were analyzed. Results 　The positive rate of VEGF, bFGF, Fas, bax, bcl-2 and bcl-xl was 77. 5%(31/40), 75 %(30/40), 20 %(8/40), 25 %(10/40), 27. 5 %(11/40) and 50%(20/40) in HCC respectively. The positive correlations between VEGF and bFGF, bcl-2 and bcl-xl were found ( P < 0. 01 respectively) . The same results were also found between bax and bcl-2, VEGF and bcl2-2 、bax and bFGF ( P < 0. 05 respectively) . Conclusion 　The angiogenesis and cell apoptosis in HCC may be regulated by the expressions of VEGF, bFGF, Fas, bax, bcl-2 and bcl-xl.

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