Abstract: Objective 　To investigate the relationship between the expression of survivin、VEGF、Ki67 and the clinicopathologic parameters in colorectal carcinoma (CRC), and evaluate their significances in predicating the prognosis. Methods 　Immunohistochemical method by two2step Power Vision was used to detect survivin、VEGF、Ki67 expression in 40 patient s with CRC. The relationship between the expression of survivin、VEGF、Ki67 and the clinicopathologic parameters, prognosis was ret rospectively analyzed. Results 　The positive rates of survivin、VEGF、Ki67 in CRC were all higher than those in matched normal tissues ( P < 0. 01) . Their expressions were related to Duke' s stages and the metastasis of lymph nodes. The expression rates of the three markers in CRC with the metastasis of lymph nodes were higher than those without metastasis ( P < 0. 05), and higher in Duke' s C、D stages than in Duke' s A、B stages ( P <0. 05) . survival rate of 3 years and 5 years were lower in those patient s with the positive expression of these markers than in those with the negative expression ( P < 0. 05) . Conclusion 　The expression of survivin、VEGF、Ki67 were associated with the development and metastasis of CRC. The patient s with expressions of survivin、VEGF、Ki67 have lower survival rates of 3 years and 5 years. We may evaluate the prognosis of CRC through the test of survivin、VEGF and Ki67.