Abstract: Objective 　To analyze the outcomes and factors affecting prognosis of advanced T3 T4 glottic carcinoma. Methods 　To review the records of 110 patient s of T3 T4 glottic squamous cell carcinoma. Sur2 vival and locoregional cont rol rates by different therapy were estimated and prognostic factors for survival and recurrence were identified. Results 　The overall survival and locoregional cont rol rates was 59. 1 % and 68. 6 % at five year, the combined methods was 72. 0 % and 76. 9 %, surgery was 50. 0 % and 60. 7 %, and radiotherapy was 41. 7 % and 56 %, respectively, there was a significant difference compared combined methods with radiotherapy or surgery ( P < 0. 05) . Survival rates of patient s for the young ( ≤60 years), jugular lymph node negative and primary lesion cont rol were 76. 5 %, 67. 8 %and 67. 3 % at five year, su2 perior to the elder ( ≥61 years) (47. 9 %), jugular lymph node metastasis (16. 7 %) and primary lesion recurrence (10. 7 %) respectively, there was a significant difference ( P < 0. 01) . Overall recurrence rate was 23. 64 %. Cont rol rates of patient s of differentiation well and jugular lymph node negative was 76. 6 % and 73. 6 %, superior to the differentiation poorly (48 %) and jugular lymph node metastasis (43. 6 %), and had a significant difference ( P < 0. 05) . Differentiation poorly and jugular lymph node metastasis was independent predictive factors for locoregional recurrence, and old, jugular lymph node metastasis and pri2 mary lesion recurrence for survival on univariate and multivariate analysis. Conclusion 　Effect of com2 bined methods was superior to the simple for advanced glottic squamous cell carcinoma. Differentiation poorly and J ugular lymph node metastasis was independent predictive factors for locoregional recurrence, and elder, jugular lymph node metastasis and primary lesion relap se for survival.