Abstract: Objective 　To observe the efficacy in the near future of nedaplatin (NDP) and cisplatin (CDDP) for the patient s with advanced esophageal carcinoma. Methods 　Collect 61cases, 30 cases in NDP t reat2 ment group (NF group), 31 cases in CDDP t reatment group (DF group), NF group use NDP 80～100 mg/m2, int ravenous drip, d1, calcium leucovorin 200 mg/ m2, int ravenous drip, d1, 2, then int ravenous bolus of 52Fu 400 mg/ m2 followed by 22 hour infusion of 52Fu 600 mg/ m2 using an ambulatory pump, d1, 2 ;DF group use CDDP 30mg/ m2, int ravenous drip, d1～3, the usage of other drugs are the same as DF group. Results 　The RR of NF group is 53. 33 %, the RR of DF group is 35. 48 %, the difference was not statisti2 cally significant ( P > 0. 05) . There is a lower digestive reaction and lower toxicity of liver and kidney in NF group. Conclusion 　The efficacy in the near future of NF group is higher than DF group and NF group is easier tolerant to the side effect, so it is fit to the olds especially and do has efficacy to the pa2 tient s failure or cannot tolerate to CDDP.