胰腺癌p27~ (kip1)、cyclinE和增殖细胞核抗原的表达及与临床病理关系研究

Expression of p27~ (kip1)、 cyclinE protein and PCNA and relationships with clinicopathology in human pancreatic cancer

摘要: 目的　探讨 p2 7kip1、cyclinE蛋白和PCNA在胰腺癌发生发展中的作用。方法　应用免疫组化SP法, 对 32例胰腺癌及癌旁组织中 p2 7kip1、cyclinE蛋白和PCNA表达进行检测。结果　p2 7kip1蛋白阳性表达率在胰腺癌组织中为 5 6 .3%, 显著低于癌旁组织 (P <0 .0 5 ), 并与癌组织分化程度及淋巴结转移相关 (P <0 .0 5 ) ;cyclinE和PCNA阳性表达率在胰腺癌组织中分别为6 8.8%和 71.9%, 均显著高于癌旁组织 (P <0 .0 5 ), 并与癌组织分化程度和淋巴结转移均相关 (P <0 .0 5 )。结论　p2 7kip1、cyclinE和PC NA可能在胰腺癌发生发展中发挥重要作用。

Abstract: Objective To investigate the role of p27 kip1, cyclinE protein and PCNA on the occurrence and progress of pancreatic cancer. Methods Expression of p27 kip1, cyclinE and PCNA in tumor tissues and adjacent tissues of 32 patients with pancreatic cancer was studied by SP immunohistochemical technique. Results p27 kip1 protein positive-expression rate in tumor tissues of pancreatic cancer was 56.3%, which was lower than that in adjacent tissues (P< 0.05), p27 kip1 protein positive-expression co...