博来霉素联合凝血酶对恶性血性胸水的疗效观察

The effect of infusing thrombin into pleural cavity for treatment of malignant pleural effusion

摘要: 目的　为了观察博来霉素联合凝血酶对恶性血性胸腔积液的治疗效果。方法　采用胸腔穿刺, 置入深静脉留置管引流胸腔积液, 灌注凝血酶, 并以凝血酶 +博来霉素及博来霉素做对照。结果　凝血酶组2 1例有效率 5 2 .4 %, 凝血酶 +博来霉素组 2 1例, 有效率 90 .5 %, 而单纯博来霉素组有效率 71.4 % (各组间比较P <0 .0 5 )。结论　凝血酶是一个安全有效抗恶性胸腔积液药物, 它可安全用于老年人, 它能增强博来霉素的疗效, 二者合用能取得更好地抗胸水效果。

Abstract: Objective To evaluate the tierapeutic effects of infusing thrombin and combined bleomycin into pleural cavity for treatment of malignant pleural effusion. Methods the pleural effusion was drain out from a intrapleural catheter and then infused thrombin,thrombin+bleomycin and bleomycin inspectively and their therapeutic effects were compared in ramdomized trial. Results the response rate of the thrombin groups?the thrombin+bleomycin groups and bleomycin groups were 52.4%?90.5% and 71.4% respectively. Side-e...